http://blog.newtbdrugs.org Working Towards a Faster Cure for Tuberculosis Fri, 03 Sep 2010 14:16:38 +0000 http://wordpress.org/?v=2.9.1 en hourly 1 http://blog.newtbdrugs.org/2010/08/this-week-in-tb-rd-24-august-2010/ http://blog.newtbdrugs.org/2010/08/this-week-in-tb-rd-24-august-2010/#comments Wed, 25 Aug 2010 04:50:49 +0000 Working Group http://blog.newtbdrugs.org/?p=1511 Last week, a paper was published in Nature by Matthew Berry, Christine Graham et al. which received a fair amount of notice. The authors presented data identifying a probable TB gene signature in people infected with TB. Initially the investigators examined genome-wide transcriptional profiles generated from RNA extracted from whole blood, purified neutrophils, monocytes, and [...]]]> http://blog.newtbdrugs.org/2010/08/this-week-in-tb-rd-24-august-2010/feed/ 0 http://blog.newtbdrugs.org/2010/08/genetic-signature-may-lead-to-better-tb-diagnosis/ http://blog.newtbdrugs.org/2010/08/genetic-signature-may-lead-to-better-tb-diagnosis/#comments Fri, 20 Aug 2010 20:33:56 +0000 Working Group http://blog.newtbdrugs.org/?p=1505 LONDON (Reuters) — Scientists have found a "genetic signature" in the blood of patients with active tuberculosis (TB) and believe their discovery could help develop better diagnostic tests for the disease, as well as better treatments.]]> http://blog.newtbdrugs.org/2010/08/genetic-signature-may-lead-to-better-tb-diagnosis/feed/ 0 http://blog.newtbdrugs.org/2010/08/glaxosmithkline-finds-compound-that-could-help-fight-superbugs/ http://blog.newtbdrugs.org/2010/08/glaxosmithkline-finds-compound-that-could-help-fight-superbugs/#comments Mon, 09 Aug 2010 20:10:49 +0000 Working Group http://blog.newtbdrugs.org/?p=1373 GlaxoSmithKline (GSK) researchers announced Wednesday that they have found a new compound that may help in the fight against drug-resistant bacteria. The findings could ultimately assist scientists in developing new antibiotics to tackle what has been called one of the world's most pressing public health problems. Last year, a report from the American Academy of Microbiology called antibiotic resistance "an international pandemic," adding that "resistance essentially is uncontrollable."]]> http://blog.newtbdrugs.org/2010/08/glaxosmithkline-finds-compound-that-could-help-fight-superbugs/feed/ 1 http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-july-27-2010/ http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-july-27-2010/#comments Tue, 27 Jul 2010 15:03:04 +0000 Working Group http://blog.newtbdrugs.org/?p=1335 The route of drug delivery for TB drugs is an interesting one with the usual (and valuable) room for debate about different methods. While the standard mode of delivery for most drugs is oral, there is ongoing discussion as to whether aerosol delivery of TB drugs may be a more suitable route of delivery for treating pulmonary TB.]]> http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-july-27-2010/feed/ 2 http://blog.newtbdrugs.org/2010/07/tag-2010-pipeline-report/ http://blog.newtbdrugs.org/2010/07/tag-2010-pipeline-report/#comments Thu, 22 Jul 2010 14:10:35 +0000 Working Group http://blog.newtbdrugs.org/?p=1312 Treatment Action Group (TAG) recently released their TAG 2010 Pipeline Report, an annual report that explores the progress and overall state of drug development in the fields of HIV, Tuberculosis, and Viral Hepatitis. The report covers the development of drugs, diagnostics, vaccines, immune-based therapies, and preventative technologies in development in each field.]]> http://blog.newtbdrugs.org/2010/07/tag-2010-pipeline-report/feed/ 0 http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-july-20-2010/ http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-july-20-2010/#comments Tue, 20 Jul 2010 16:09:32 +0000 Working Group http://blog.newtbdrugs.org/?p=1293 On Friday, July 16th, the fourth annual New England TB Symposium took place at the Broad Institute, in Cambridge, Massachusetts.  The symposium was in collaboration with the US-Japan Cooperative Medical Sciences Program: 45th Tuberculosis and Leprosy Research Conference which preceded the symposium at the Broad from July 13-15th. A brief synopsis of some of the symposium [...]]]> http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-july-20-2010/feed/ 0 http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-13-july-2010/ http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-13-july-2010/#comments Tue, 13 Jul 2010 23:23:32 +0000 Working Group http://blog.newtbdrugs.org/?p=1264 Last week we highlighted the Xpert® MTB/RIF assay for diagnostic testing. This week, we will briefly describe the GenoType® MTBDRplus assay. The GenoType® MTBDRplus assay uses PCR to amplify biotin-labeled amplicons (single-stranded DNA sequences) of M. tb from sputum.]]> http://blog.newtbdrugs.org/2010/07/this-week-in-tb-rd-13-july-2010/feed/ 0 http://blog.newtbdrugs.org/2010/07/the-outcasts-of-tuberculosis/ http://blog.newtbdrugs.org/2010/07/the-outcasts-of-tuberculosis/#comments Mon, 12 Jul 2010 14:57:47 +0000 Working Group http://blog.newtbdrugs.org/?p=1253 http://blog.newtbdrugs.org/2010/07/the-outcasts-of-tuberculosis/feed/ 1 http://blog.newtbdrugs.org/2010/07/dual-infections-of-tb-and-aids-make-each-harder-to-treat/ http://blog.newtbdrugs.org/2010/07/dual-infections-of-tb-and-aids-make-each-harder-to-treat/#comments Fri, 09 Jul 2010 19:55:10 +0000 Working Group http://blog.newtbdrugs.org/?p=1238 Tuberculosis infects nearly ten million people each year and kills nearly two million. It is primarily a lung disease that spreads easily among people with weakened immune systems. Sub-Saharan Africa is still the epicenter of the HIV/AIDS disaster, but it is also becoming the epicenter of tuberculosis.]]> http://blog.newtbdrugs.org/2010/07/dual-infections-of-tb-and-aids-make-each-harder-to-treat/feed/ 0 http://blog.newtbdrugs.org/2010/07/tb-alliance-new-potential-tb-drugs-to-be-investigated-against-multiple-neglected-diseases/ http://blog.newtbdrugs.org/2010/07/tb-alliance-new-potential-tb-drugs-to-be-investigated-against-multiple-neglected-diseases/#comments Wed, 07 Jul 2010 14:30:56 +0000 Working Group http://blog.newtbdrugs.org/?p=1211 New York, United States and Geneva, Switzerland — July 7, 2010 The TB Alliance and Drugs for Neglected Diseases Initiative (DNDi) announced today a unique first-ever royalty-free license agreement between two not-for-profit drug developers that speeds progress toward markedly improved therapy of multiple neglected diseases.]]> http://blog.newtbdrugs.org/2010/07/tb-alliance-new-potential-tb-drugs-to-be-investigated-against-multiple-neglected-diseases/feed/ 0